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1. Tutorial

Estimating selection pressures on alignments of coding sequences Analyses using HyPhy Edited by Sergei L Kosakovsky Pond Art F Y Poon and Simon D W Frost Theory 1 1 Introduction Understanding the selective pressures that have shaped genetic variation is a central goal in the study of evolutionary biology As nonsynonymous mu tations can directly affect protein function they are more likely to influence the fitness of an organism than mutations that leave the amino
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